Matthew R. Francis is right, 'dark matter of the genome' is a really bad metaphor.
Matthew R. Francis – Writer of science, blogger of physics and astronomy, director of CosmoAcademy, writes:
“Physicists are serial offenders when it comes to cross-disciplinary meddling. Whether it’s a theoretical cosmologist claiming to solve consciousness or a professor smugly claiming all other sciences are “soft”, physicists are too often quick to pass judgement on other fields. So, I’m a little worried about coming off that way when I criticize a bad habit in biology of referring to the “dark matter of the genome” or other similar phrases.”
Read more here.